I disagree with the premise, the Holocaust was unique. It was unique in its effectiveness, it was a meticulously planned machinery of death the world has never seen before or after.
There were once 100 million Natives living on the two American continents.
Most estimates (and all recent ones) put that number around 50 mln, the vast majority of whom died from disease, rather similarly to how the black death from asia killed the majority of europe and the middle east two hundred years prior.
Did it enable colonialism? Yes. Was it meticulously planned? No.
This is genocide denial.
They were rounded up into camps, the US army brought the buffalo to near extinction to starve the natives, scalp hunting! It was systematic and deliberate.
There was a whole industry propped up by the military, church, and schools to kill them and take their land, remove their culture, take away their religion, enslave them, and constantly push them away. It was very much planned.